Sumy Pharmaceuticals Pvt. Ltd.

Losartan is an angiotensin receptor blocker (ARB). It blocks a chemical that tightens blood vessels. This makes blood vessels relax, which lowers blood pressure and allows more blood and oxygen to get to your heart and other organs. Amlodipine is a calcium channel blocker.

A combination of antihypertensive agents can better control blood pressure and reduce the number and severity of side effects than a monotherapy. Since both CCBs (calcium channel blockers) and ARBs (angiotensin II receptor type-1 blockers) are current and effective antihypertensive drugs, this study assessed the synergistic antihypertensive effects as well as the optimal combination ratio of these two drugs. The combination significantly lowered the SBP, and there is a positive correlation between the reduction in blood pressure and the improvement in arterial endothelium-dependent relaxation. In addition, the combination therapy decreased both the cardiac mass and left ventricular weight to a greater extent than with either amlodipine or losartan alone.