Angipril
Enalapril maleate 2.5 - 5mg Tab
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Mode of action
It is an angiotensin-converting-enzyme (ACE) inhibitor. The angiotensin I is converted to angiotensin II in the presence of an angiotensin-converting enzyme (ACE). The Angiotensin II constricts blood vessels, increasing blood pressure. By inhibiting the ACE, enalaprilat, the active metabolite of enalapril, decreases levels of angiotensin II leading to less vasoconstriction a decreased blood pressure.
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Indication
- Hypertension
- Heart failure
- Left ventricular dysfunction
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Side effects
Headache, peripheral oedema, angioedema, flushing, hypotension, bradycardia, dizziness
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Precaution
Neonate, hypersensitivity, children, elderly, liver disease, gout, hyperlipidemia
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Dose
Hypertension
Adult: 5mg at bed time. Maintenance dose: 10-20mg once daily increased up to 40mg in divided dose in severe hypertension. Max dose: 40mh/ day
Child: 80mcg/kg once dailyHeart failure
Adult: Initially, 2.5mg daily. Maintenance dose: 20mg once daily as a single dose or in 2 divided doses up to 40mg daily in 2 divided doses.