Losartan potassium 25 - 50mg Tab
  • Mode of action

    It is an angiotensin II receptor type 1 (AT₁) antagonist. It competitively inhibits the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. Thus inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure.

  • Indication

    • Hypertension
    • Diabetic nephropathy in type 2 DM
    • Management of heart failure

  • Side effects

    Headache, peripheral oedema, angioedema, flushing, hypotension, bradycardia and dizziness

  • Precaution

    Diuretic, renal artery disease, elderly, hepatic impairment, monitor serum-potassium concentration

  • Dose

    Adult: 50mg once daily, increased to 100mg as a single dose or in 2 divided dose if needed.
    Child: Below 6years initially 100mcg/kg increased to a max of 50 mg once daily. Elderly: ≥75 years, initially 25mg once daily.
    Diabetic nephropathy in type 2 DM,
    Adult: 50mg once daily increased to 100mg daily as a single dose or in 2 divided doses if needed. Elderly: ≥75yrs initially 25mg once daily.