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Angitan
Losartan potassium 25 - 50mg Tab
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Mode of action
It is an angiotensin II receptor type 1 (AT₁) antagonist. It competitively inhibits the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. Thus inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure.
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Indication
- Hypertension
- Diabetic nephropathy in type 2 DM
- Management of heart failure
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Side effects
Headache, peripheral oedema, angioedema, flushing, hypotension, bradycardia and dizziness
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Precaution
Diuretic, renal artery disease, elderly, hepatic impairment, monitor serum-potassium concentration
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Dose
Hypertension
Adult: 50mg once daily, increased to 100mg as a single dose or in 2 divided dose if needed.
Child: Below 6years initially 100mcg/kg increased to a max of 50 mg once daily. Elderly: ≥75 years, initially 25mg once daily.
Diabetic nephropathy in type 2 DM,
Adult: 50mg once daily increased to 100mg daily as a single dose or in 2 divided doses if needed. Elderly: ≥75yrs initially 25mg once daily.