Dermafine Cream

Dermafine Cream
Terbinafine 1% w/w Cream
  • Mode of action

    It is an allylamine derivative, acts by inhibiting squalene monooxygenase, thus blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. This inhibition also results in an accumulation of squalene, which is a substrate to 2, 3- oxydo squalene by squalene monooxygenase. The resultant high concentration of squalene and decreased amount of ergosterol are both to contribute antifungal activity.

  • Indication

    • Itching
    • Burning
    • Scaling associated with jock itch
    • Athlete’s foot
    • Ring worm
    • Fungal skin of skin

  • Side effects

    Burning, allergy, redness, anorexia, abdominal pain, taste disturbances

  • Precaution

    Hypersensitivity, hepatic impairment, pregnancy, lactation

  • Dose

    Dermatophytosis
    Adult: 250mg once a day for 2-4 weeks
    Child: 10-20kg: 62.5mg once daily for 2 weeks, 20-40kg; 120mg for 2 weeks