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Diuret S
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Mode of action
Frusemide: Acts by blocking the Na⁺ K⁺-2Cl⁻ cotransport (NKCC2)
Spironolactone; it is a specific antagonist of aldosterone acts through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule causes increased amounts of sodium and water to be excreted, while potassium is retained. (Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na⁺ K⁺-ATPase and the Nat channel involved in a Na+ K+ transport in the distal tubule. It binds to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys).
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Indication
- Heart failure
- Liver cirrhosis
- Hypertension
- Influenza
- Water poisoning and
- Certain kidney diseases
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Side effects
Fluid electrolyte imbalance, blurred vision, dizziness, photosensitivity, bone marrow depression. glycosuria, hyperglycemia, ototoxicity, hypotension, anorexia and excessive urination
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Precaution
Renal and hepatic disease, gout, impaired micturation, pregnancy, lactation
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Dose
Hypertension, CHF and oedema,
Adult: Per tab contains frusemide 20mg and spironolactone 50mg 1-4 tabs/day