Diuret S

Diuret S Tab
Frusemide 20mg + Spironolactone 50 mg Tab
  • Mode of action

    Frusemide: Acts by blocking the Na⁺ K⁺-2Cl⁻ cotransport (NKCC2)

    Spironolactone; it is a specific antagonist of aldosterone acts through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule causes increased amounts of sodium and water to be excreted, while potassium is retained. (Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na⁺ K⁺-ATPase and the Nat channel involved in a Na+ K+ transport in the distal tubule. It binds to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys).

  • Indication

    • Heart failure
    • Liver cirrhosis
    • Hypertension
    • Influenza
    • Water poisoning and
    • Certain kidney diseases

  • Side effects

    Fluid electrolyte imbalance, blurred vision, dizziness, photosensitivity, bone marrow depression. glycosuria, hyperglycemia, ototoxicity, hypotension, anorexia and excessive urination

  • Precaution

    Renal and hepatic disease, gout, impaired micturation, pregnancy, lactation

  • Dose

    Hypertension, CHF and oedema,
    Adult: Per tab contains frusemide 20mg and spironolactone 50mg 1-4 tabs/day