Frusemide: Acts by blocking the Na⁺ K⁺-2Cl⁻ cotransport (NKCC2)
Spironolactone; it is a specific antagonist of aldosterone acts through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule causes increased amounts of sodium and water to be excreted, while potassium is retained. (Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na⁺ K⁺-ATPase and the Nat channel involved in a Na+ K+ transport in the distal tubule. It binds to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys).
Fluid electrolyte imbalance, blurred vision, dizziness, photosensitivity, bone marrow depression. glycosuria, hyperglycemia, ototoxicity, hypotension, anorexia and excessive urination
Renal and hepatic disease, gout, impaired micturation, pregnancy, lactation
Hypertension, CHF and oedema,
Adult: Per tab contains frusemide 20mg and spironolactone 50mg 1-4 tabs/day