Glipan
Glimepiride 1, 2, 3 & 4mg Tab
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Mode of action
It is a sulphonyl urea derivative under the 2nd generation. It binds with the sulphonyl receptor on the pancreatic β-cell, causes the depolarization by reducing conductance of ATP sensitivity K⁺ channels, so enhances the Ca+ influx degranulation which results in secretion of insulin.
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Indication
- Type 2 DM
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Side effects
NVD, erythema, urticaria, leucopenia, thrombocytopenia, aplastic anemia, blurred vision, jaundice
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Precaution
Increased risk of CV mortality, hepatic and renal impairment, hepatic cirrhosis, pregnancy, lactation
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Dose
Type 2 DM
Adult: 1-2mg daily. Maintenance: 4mg daily. Max: 6mg daily.