Glipan

Glimepiride 1, 2, 3 & 4mg Tab
  • Mode of action

    It is a sulphonyl urea derivative under the 2nd generation. It binds with the sulphonyl receptor on the pancreatic β-cell, causes the depolarization by reducing conductance of ATP sensitivity K⁺ channels, so enhances the Ca+ influx degranulation which results in secretion of insulin.

  • Indication

    • Type 2 DM

  • Side effects

    NVD, erythema, urticaria, leucopenia, thrombocytopenia, aplastic anemia, blurred vision, jaundice

  • Precaution

    Increased risk of CV mortality, hepatic and renal impairment, hepatic cirrhosis, pregnancy, lactation

  • Dose

    Type 2 DM
    Adult: 1-2mg daily. Maintenance: 4mg daily. Max: 6mg daily.