It is a sulphonyl urea derivative under the 2nd generation. It binds with the sulphonyl receptor on the pancreatic β-cell, causes the depolarization by reducing conductance of ATP sensitivity K⁺ channels, so enhances the Ca+ influx degranulation which results in secretion of insulin.
NVD, erythema, urticaria, leucopenia, thrombocytopenia, aplastic anemia, blurred vision, jaundice
Increased risk of CV mortality, hepatic and renal impairment, hepatic cirrhosis, pregnancy, lactation
Type 2 DM
Adult: 1-2mg daily. Maintenance: 4mg daily. Max: 6mg daily.