Itraconazole 100mg Capsule
  • Mode of action

    Itraconazole 100mg Capsule

    • A triazole antifungal drug
    • Has a broader spectrum of activity than fluconazole
    • Inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis which is required in fungal cell wall synthesis
    • Has great affinity for highly keratinized tissues such as skin and nails, as well as for the vaginal wall lining
    • First choice of drug for the treatment of Candida Onchomycosis.
  • Indication

    Dermatophytosis, Vulvovaginal candidiasis, oculomycosis, Aspergillosis, Cryptococcosis, Candidiasis

  • Dose

    • Blastomycosis/histoplasmosis: 200 mg once daily, length of therapy varies from 1 day to >6 months depending on the condition and mycological response.
    • Aspergillosis: 200-400 mg/day.
    • Onychomycosis: 200 mg once daily for 12 consecutive weeks.
    • Life-threatening infections: Loading dose: 200 mg 3 times/day (600 mg/day) should be given for the first 3 days of therapy.
    • Oropharyngeal and esophageal candidiasis: Oral solution: 100-200 mg once daily.