Ketosum
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Mode of action
lt is an imidazole derivative, interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. Results in inhibits ergosterol synthesis, resulting in increased cellular permeability.
Other mechanisms may involve the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. It can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone.
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Indication
- Skin fungal infection
- Systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis chromomycosis, and paracoccidioidomycosis
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Side effects
Burning, itching, local hypersensitivity, redness and stinging
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Precaution
Hypersensitivity and lactation
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Dose
Adult: As 2% cream, apply 1-2 times daily to cover the affected and surrounding area until at least a few days after disappearance of symptom