Myodip AT

Myodip AT
  • Indication

    Atenolol is a cardio selective beta blocker. Amlodipine is a dihydropyridine calcium-channel blocker that blocks the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.
    Combination of the two drugs results in additive antihypertensive action.
    Absorption: Amlodipine: Plasma levels peak 6-12 hour after oral admin; absolute bioavailability is estimated to be 64-90%.
    Atenolol: Absorption is rapid and consistent but incomplete; about 50% of an oral dose is absorbed in the GI tract; plasma levels peak 2-4 hr after oral admin.

    Distribution: Amlodipine: 93% bound to plasma proteins. Atenolol: 6-16% bound to plasma proteins.

  • Side effects

    Headache, hypotension, dizziness, breathlessness, fatigue, muscle cramps, bradycardia, palpitations, flushing, oedema, dyspnoea, dyspepsia, cold extremities. Drowsiness, chestpain & impotence rarely. Hypersensitivity reactions.

  • Dose

    Oral
    Chronic stable angina, Hypertension
    Adult: Per tablet contains atenolol 25 or 50 mg and amlodipine (as besylate) 5 mg: 1 tab once daily, may increase to 2 tablets daily if needed.
    Elderly: Per tablet contains atenolol 25 mg and amlodipine (besylate) 5 mg: Initiate with 1 tablet daily.
    Renal impairment: Per tablet contains atenolol 25 mg and amlodipine (besylate) 5 mg: Initiate