Metformin and sitagliptin are oral diabetes medicines that help control blood sugar levels.
Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating.
Metformin and sitagliptin is a combination medicine that is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. This medicine is not for treating type 1 diabetes.
Metformin-sitagliptin immediate release:
-Patients not currently treated with metformin: Metformin 500 mg-sitagliptin 50 mg orally twice a day
Patients already treated with metformin: Sitagliptin 50 mg and the dose of metformin previously prescribed (500 mg or 1000 mg) orally twice a day. Metformin 1000 mg-sitagliptin 50 mg orally twice a day is recommended for patients already taking metformin 850 mg orally twice a day.
Metformin-sitagliptin extended release:
-Patients not currently treated with metformin: Metformin 1000 mg-sitagliptin 100 mg orally once a day
-Patients already treated with metformin: Sitagliptin 100 mg and the dose of metformin previously prescribed (500 mg or 1000 mg) once a day. For patients taking metformin immediate-release 850 mg or 1000 mg twice a day, the recommended dose is two tablets of sitagliptin metformin 1000 mg-50 mg sitagliptin taken together once a day.