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Normachol
Atorvastatin Calcium 10 - 20mg
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Mode of action
It is a selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels. The decreased hepatic cholesterol levels stimulate up regulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.
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Indication
- Hypercholesterolemia
- Primary prevention of coronary heart disease>
- Myocardial infarction
- Stroke
- Angina
- Coronary revascularization
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Side effects
Anorexia, alopecia, thrombocytopenia, dizziness, insomnia, bronchitis, rashes, rhinitis, and abdominal cram
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Precaution
Alcohol consumption, liver disease, hypothyroidism, lactation
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Dose
Hypercholesterolemia, Primary prevention of coronary heart disease
Adult: Initially, 10 or 20 mg daily may increase at 4-week intervals. May increase with 40mg once daily in patient who require 45% reduction of LDL, Max dose 80 mg/day
Child: Initially, 10-80mg daily. Adjust dose based upon the response. Max dose: 20mg daily