Normachol

Atorvastatin Calcium 10 - 20mg
  • Mode of action

    It is a selectively and competitively inhibits the hepatic enzyme HMG-CoA reductase, which is responsible for converting HMG-CoA to mevalonate in the cholesterol biosynthesis pathway, this results in a subsequent decrease in hepatic cholesterol levels. The decreased hepatic cholesterol levels stimulate up regulation of hepatic LDL-C receptors which increases hepatic uptake of LDL-C and reduces serum LDL-C concentrations.

  • Indication

    • Hypercholesterolemia
    • Primary prevention of coronary heart disease>
      • Myocardial infarction
      • Stroke
      • Angina
      • Coronary revascularization

  • Side effects

    Anorexia, alopecia, thrombocytopenia, dizziness, insomnia, bronchitis, rashes, rhinitis, and abdominal cram

  • Precaution

    Alcohol consumption, liver disease, hypothyroidism, lactation

  • Dose

    Hypercholesterolemia, Primary prevention of coronary heart disease
    Adult: Initially, 10 or 20 mg daily may increase at 4-week intervals. May increase with 40mg once daily in patient who require 45% reduction of LDL, Max dose 80 mg/day
    Child: Initially, 10-80mg daily. Adjust dose based upon the response. Max dose: 20mg daily