OHM is a substitutes benzimidazole gastric anti secretory agent and is also known as PPI. It blocks the final step in gastric acid selection by specific inhibition of H+/K+ATPase enzyme, which is present on the surface of the gastric parietal cell.
Usual Adult Dose for Gastric Ulcer
40 mg orally once a day
-Duration of therapy: 4 to 8 weeks
Use: Short-term treatment of active benign gastric ulcer
Usual Adult Dose for Erosive Esophagitis
Treatment: 20 mg orally once a day
-Duration of therapy: 4 to 8 weeks
Maintenance: 20 mg orally once a day
Usual Adult Dose for Duodenal Ulcer
20 mg orally once a day
-Duration of therapy: 4 weeks
Use: Short-term treatment of active duodenal ulcer
Usual Adult Dose for Helicobacter pylori Infection
Dual therapy: 40 mg orally once a day, taken concomitantly with clarithromycin
-Duration of therapy: 14 days
Usual Adult Dose for Zollinger-Ellison Syndrome
Initial dose: 60 mg orally once a day
Maximum dose: 360 mg/day (as 120 mg orally 3 times a day)
Usual Adult Dose for Gastroesophageal Reflux Disease
20 mg orally once a day
-Duration of therapy: Up to 4 weeks
Use: Treatment of heartburn and other symptoms associated with GERD
Usual Adult Dose for Dyspepsia
Over-the-Counter (OTC) formulations: 20 mg orally once a day in the morning
-Duration of therapy: 14 days