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Act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H+/K+ ATPase) of the gastric parietal cells, which is the terminal step in acid production
Significantly more effective than H2 antagonists
Used to treat gastroesophageal reflux disease (GERD), a condition that causes gastric juices to flow upward from the stomach and into the esophagus
Also treats conditions in which the stomach makes excess acid, including Zollinger-Ellison syndrome