Chloramphenicol 5% w/v t Benzocaine 1% wlv Ear Drop
  • Mode of action

    Chloramphenicol: It is broad spectrum antibiotics, acts by inhibiting the bacterial protein synthesis. It binds to 50s ribosome subunit- interfere with peptide bond formation and transfer of peptide chain from ‘p’ site.
    Benzocaine: it is a local anaesthetic, binds to the sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited, thereby blocking the initiation and conduction of nerve impulses.

  • Indication

    • Otitis externa.
    • Ocular infection
    • Otic Pain

  • Side effects

    Headache, ocular burning, dry eye, hyperaemia, keratitis, pruritus, blurred vision, bitter taste, and epistaxis.

  • Precaution

    Pregnancy, lactation, remove contact lenses prior to eye admin

  • Dose

    Ocular infection
    Adult: Instill 1 drop every 2 hrs.
    Otitis externa
    Adult: Instill 2-3 drops into ear bid or tid.